Proteomics is the study of the proteome, or the systematic, large-scale study of a complete set of proteins produced by an organism, tissue, or cell line. A variety of techniques are used to understand the function of proteins and how they interact with each other.
Both protein expression technologies and proteomics tools, instruments and equipment and supplies enable scientists to study and analyze a wide variety of proteins.
Proteomics Tools and Equipment
Protein expression is the process of generating a specific protein by manipulating the gene expression in a living organism. The organisms utilized for protein expression must be easy to culture and maintain, grow rapidly and produce large amounts of protein. Whether your lab team works to identify proteins or analyze complex mixtures of proteins, Avantor® carries the proteomics tools, equipment and products necessary for highly efficient processes and reliable results. We also offer proteomics resources to help make your scientific vision a reality.
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Protein expression is the process of generating a specific protein by manipulating the gene expression in a living organism. The organisms used for protein expression technology must be easy to culture and maintain, grow rapidly, and produce large amounts of protein.
Learn the importance of protein purification, methods used by biomanufacturers, the role it plays in the search for life saving solutions and how we can provide the support and guidance you may need.
Getting accurate and high-quality results depends on having the supplies and equipment you need to do your job efficiently and effectively.
Protein Expression and Purification
We are a leading supplier of protein expression and purification products, including high-quality reagents and easy-to-use purification systems.
For consistent lot-to-lot protein induction performance.
Created from a natural source of cellulose with the ability to selectively diffuse molecules across a semi-permeable membrane
Protein A chromatography resins and columns for antibodies purification.
Reagents for efficient cell lysis and maximum protein extraction yields.
See our extensive range of solutions for protein purification.
A variety of reagents for isolating one or more proteins from a complex mixture, including cells, tissues and whole organisms.
Designed to emulsify, blend, or mix organic and inorganic materials allowing sample prep for downstream applications.
Tangential Flow Filtration systems for concentration, desalting, and buffer exchange processes.
Centrifugal devices with UF membranes are ideal to concentrate, purify and desalt peptides, proteins and nucleic acid samples.
Protein Electrophoresis and Blotting
Obtain specialized protein gels, or find power supplies and accessories that match your electrophoresis chamber. Our offerings help you match your supplies to proteomics products and experimental requirements.
The most commonly used gels for their versatility with buffers and ability to generate reproducible results.
Choose pre-cut sheets in desired grade, blotter art, LSD blotter, in many common dimensions for optimal compatibility.
Sets of standards used to identify the approximate size of a molecule run on a gel during electrophoresis.
Different Power supply systems compatible with your electrophoresis and blotting apparatus.
Choose from different number of wells, thicknesses and sizes among the precast gels for compatibility with samples and equipment.
With clamps to guarantee the assembly stays upright, these systems facilitate fast gel runs with even cooling resulting in distinct bands.
Protein Detection and Analysis
Discover the proteomics tools your lab needs for high-throughput protein detection and analysis. Avantor carries a large assortment of proteomics chromatography products, antibodies and more.
Choose from our broad range of chromatography columns for HPLC and UHPLC.
We offer HPLC and UHPLC equipment.
Set your lab up for success with antibodies from the brands you trust.
View our complete offering of ELISA assays.
Selection of films used for a wide range of electrophoretic and autoradiography applications.
High throughput screening microplates are available as non-sterile, pre-sterile, or sterile for your assay testing and storage preferences.
Plates available with different binding options that can be used with hydrophobic and hydrophilic molecules for immunoassays.
Robust, compact, high-value microplate readers for all your biological assays.
We offer microplate washers for every laboratory application.
Choose from our broad range of reagents for western blot detection.
See our complete solutions for western blot detection.
What Is Proteomics?
What Is a Proteome?
A proteome is the entire set of proteins expressed by a cell line, tissue, or organism. The same term is also used to describe various proteins produced from certain cell or tissue types at a particular time.
The proteome of an organism is the expression of its genome. While the genome remains stable, the proteome is dynamic and changes in response to internal and external factors.
What Is Protein Expression?
Protein expression is the process of generating a specific protein by manipulating the gene expression in a living organism. The organisms used for protein expression must be easy to culture and maintain, grow rapidly and produce large amounts of protein.
Why Is Proteomics Important?
Proteomics is important because by studying proteins within cells we can gain more knowledge about how cellular life functions. It is the proteins within the cell that provide the structure, produce energy and allow communication, movement and reproduction.
While knowing and understanding the human genome and genomics is important, this genetic information is static. Proteomics explores the dynamic nature of proteins and expands our understanding of how altered protein expression can result in diseased states. It can be used for prognostic and diagnostic purposes.
Additionally, by understanding protein markers better, more targeted approaches can be used for therapeutic treatment plans and to develop more effective drugs.
By combining proteomics with genomics, biomedical research will be able to advance its development of diagnostic and therapeutic products.
What Tools Are Used in Proteomics?
Proteomics tools commonly used include:
- Western Blot
Detects specific protein molecules in a mixture of proteins. - Chromatography
Separates complex mixtures at a high speed and provides high-resolution and high sensitivity. - Mass Spectrometry
Identifies and quantifies proteins by measuring the mass-to-charge ratio of ions. - Protein Arrays
Capable of identifying proteins, protein interactions, antibody-antigen interactions and enzyme-substrate interactions. - Enzyme-Linked Immunosorbent Assay (ELISA)
A plate-based assay capable of detecting and quantifying proteins.
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