HATU (O-(7-Aza-1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate), Novabiochem®Supplier: Novabiochem (Merck biosciences)
1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide, hexafluorophosphate
A highly efficient coupling reagent for solid and solution phase peptide synthesis.
In comparative studies HATU has been found to give better coupling yields with less enantiomerization that HBTU, TBTU or PyBOP® [1-3]. It is particularly effective at coupling to N-alkyl amines where other coupling reagents give poor yields and is the preferred reagent for loading resins bearing secondary amino groups.
MW: 380.2 g/mol
Melting Pt: 186 °C
Storage Temperature: Refrigerator
CAS Number: 148893-10-1