Affinity chromatography media, MabSelect SuRe™ LX

Supplier: Cytiva
MabSelect™
17-5474-02EA 7616.19 EUR
17-5474-02 17-5474-01
Affinity chromatography media, MabSelect SuRe™ LX
Protein Purification Protein Purification Resins
MabSelect SuRe™ LX is a protein A affinity medium with very high dynamic binding capacity at extended residence times and is developed for high titer antibody processes.

  • Alkali-tolerant rProtein A ligand withstands rigorous CIP and sanitisation procedures with 0,1 to 0,5 M NaOH
  • Reduces the risk of product contamination and carryover
  • Improves performance and reduces overall costs
  • High dynamic binding capacity (DBC) for high titer cultures reduces process time and amount of medium used
  • Generic elution profile for different monoclonal antibodies enables platform approach to purification
  • High flow agarose matrix allows the processing of large feed volumes

MabSelect SuRe LX shares features and benefits of MabSelect and MabSelect SuRe such as a rigid, high-flow agarose matrix that ensures excellent pressure/flow properties, low non-specific binding that leads to low impurity levels in the eluate pool, and an oriented ligand coupling for optimal binding capacity. It also features the same alkali-tolerant rProtein A ligand as MabSelect SuRe. This ligand provides greater stability than conventional protein A-based media in the alkaline conditions used in cleaning-in-place (CIP) and sanitization protocols. The enhanced alkali stability of MabSelect SuRe improves process economy and product quality; cleaning can be performed with cost-effective reagents such as sodium hydroxide eliminating the need for expensive and hazardous cleaning agents such as Gua-HCl.

Process economy is also improved by the increased dynamic binding capacity of MabSelect SuRe LX. Just as for MabSelect SuRe, the novel ligand construct of MabSelect SuRe LX has been proven to have an increased stability towards proteases. Therefore, the level of leakage of the MabSelect SuRe LX ligand during elution is low. Demonstrated to give generic elution conditions for different monoclonal antibodies which can be applied also to MabSelect SURe LX since it utilizes the same ligand. This is an advantage when designing generic purification platform processes. The feature is also correlated to the construction of the MabSelect SuRe ligand. Available in a range of different bulk pack sizes and convenient pre-packed formats for easy scale-up and process development. As member of the BioProcess media range, MabSelect SuRe meets industrial demands with security of supply and comprehensive technical and regulatory support.

Alkali tolerance, high capacity and low ligand leakage in combination with the rigid base matric makes MabSelect SuRe LX highly suitable for purification of monoclonal anitbodies for clinical applications. MabSelect SuRe LX is a member of the MabSelect family of affinity chromatography media for the capture of monoclonal antibodies (MAbs) at process scale.
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