Vincristine sulphate, white powder

Supplier: MP Biomedicals

ICNA0219068705EA 382 EUR
ICNA0219068705 ICNA0219068725 ICNA0219068701
Vincristine sulphate, white powder
Vincristine sulphate

Soluble in water (50% w/v); soluble in methanol; moderately soluble in chloroform; very slightly soluble in ethanol; insoluble in diethyl ether.

Vincristine sulphate is used to treat acute leukaemia, malignant lymphoma, Hodgkin′s disease, acute erythraemia, acute panmyelosis, breast cancer, Kaposi′s sarcoma and testicular cancer. It is widely used in cancer research. It is used to study multi-drug resistance. It is used to inhibit cell cycle progression at M-phase and to inhibit monoamine oxidase (MAO).

Vincristine is a plant alkaloid that inhibits microtubule assembly by binding tubulin and inducing coiled spiral aggregate formation. It arrests cell cycle in G2/M-phase by blocking mitotic spindle formation. Vincristine triggers Raf-1 activation, phosphorylation of bcl-2-family proteins, induction of p53 expression, and apoptosis in several tumor cell lines. It inhibits VEGF production in leukemia cell lines. It is a substrate for Pgp and CYP3A4. MRP1 transports vincristine in an ATP- and GSH-dependent manner. Vincristine has some immunosuppressant effect. Vincristine may also interfere with amino acid, cyclic AMP, and glutathione metabolism, calmodulin-dependent Ca2+-transport, cellular respiration, and nucleic acid and lipid biosynthesis.

Formula: C₄₆H₅₈N₄O₁₄S
MW: 923.04
Melting Pt: 273…281 °C (lit.)
MDL Number: MFCD00084729
CAS Number: 2068-78-2
EINECS: 218-190-0
UN: 2811
ADR: 6.1,II

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