Anti-ITGAM Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: ICRF44]

Supplier: Tonbo Biosciences
20-0118-T025EA 35.3 EUR
20-0118-T025 20-0118-T100
Anti-ITGAM Mouse Monoclonal Antibody (APC (Allophycocyanin)) [clone: ICRF44]
The ICRF44 antibody reacts with human CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1, ICAM-2, ICAM-3 and ICAM-4 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

Type: Primary
Antigen: ITGAM (integrin, alpha M (complement component 3 receptor 3 subunit))
Clonality: monoclonal
Clone: ICRF44
Conjugation: APC (Allophycocyanin)
Host: Mouse
Isotype: IgG1 Kappa
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