Anti-CTLA4 Mouse monoclonal antibody [clone: BNI3]

Supplier: Tonbo Biosciences
70-1529-U100EA 86.2 EUR
Anti-CTLA4 Mouse monoclonal antibody [clone: BNI3]
The BNI3 antibody is specific for human CD152, commonly known as CTLA-4, a 33-37 kDa protein expressed as a homodimer on the surface of activated T and B cells, and on thymocytes. CTLA-4 is structurally similar, yet functionally disparate, to the T cell co-stimulatory molecule CD28. Both CTLA-4 and CD28 interact with the co-stimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells, with CTLA-4 displaying a higher avidity than CD28. While CD28 typically delivers a potent co-stimulatory signal in support of T cell activation, CTLA-4 appears to act as a negative regulator of T cell activation and may contribute to the suppressor function of Treg cells.

Type: Primary
Antigen: CTLA4 (cytotoxic T-lymphocyte-associated protein 4)
Clonality: monoclonal
Clone: BNI3
Conjugation: unconjugated
Host: Mouse
Isotype: IgG2a Kappa
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