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Anti-MMP2 Rabbit Polyclonal Antibody

Fournisseur: Thermo Scientific

In Western Blot, bands can be seen at approximately 72kDa (proform) and 62kDa (active form). Antigen retrieval is not required for IHC. Suggested positive control: Injured rat nerve lysate. Loss of negative growth regulation and high invasive potential are neoplastic traits often associated with abnormal expression of matrix matalloproteinases. MMP-2, the signalling mechanism for cells to begin migration, triggers the movement when it splits laminin-5 and exposes and integrin-binding site on this component of epithelial basement membrane. The changed form of laminin was found in tumors and in tissues being altered. The activated form of MMP2, however, is not found in benign tumors. Thus detection of the enzyme is a possible early indicator of tumor activity.

Type: Primary
Antigen: MMP2
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Rat, Mouse, Human, Chicken



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Taille Cdt Numéro de catalogue VWR Quantité
100 µL 100 µl PIEAPA116667 Blocked
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SPÉCIFICATIONS

Symbole antigène MMP2
Nom de l'antigène Matrix Metalloproteinase 2
Réactivité Chicken, Mouse, Human, Rat
Conjugaison Unconjugated
Clonalité Polyclonal
Type d' Anticorps Primary
Hôte Rabbit
Isotype IgG
Western Blot Yes
ELISA Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Flow Cytometry Yes
Antigen synonyms Collagenase Type 4 alpha, 72kD type IV collagenase, Gelatinase neutrophil, 72 kDa gelatinase, CLG4A, Mat, Gelatinase alpha, CLG 4A, Gelatinase A, CLG4
Gene ID 4313, 386583, 17390, 81686
Mesures de concentration 1 mg/ml
Immunogen A synthetic peptide corresponding to residues 475-490 of human MMP-2: MGPLLVATFWPELPEK
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer PBS, 0.05% sodium azide
Température de stockage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping Temperature Ice
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