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Anti-LOX Rabbit Polyclonal Antibody

Fournisseur: Thermo Scientific

PA1-16953 is specific for the ~58 kDa LOX protein. This is a highly glycosylated protein and therefore, other bands may be seen at ~32 kDa (non-glycosylated form) 50 kDa and 58 kDa (glycosylated forms). Suggested positive control: human and mouse kidney lysate, antigen standard for LOX (transient overexpression lysate), human kidney protein, mouse kidney protein. Lysyl oxidase (LOX), a copper-containing amine oxidase, belongs to a heterogeneous family of enzymes that oxidize primary amine substrates to reactive aldehydes. It plays a vital role in the formation and repair of the extra cellular matrix. As well, LOX is a multifunctional enzyme having diverse biological functions such as developmental regulation, tumor suppression, cell motility and cellular senescence. The secreted form of LOX is responsible for the invasive properties of hypoxic human cancer cells. Thus, it is essential for hypoxia-induced metastasis and is a good therapeutic target for preventing and treating metastases.

Type: Primary
Antigen: LOX
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Human



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Taille Cdt Numéro de catalogue VWR Quantité
100 µL 100 µl PIEAPA116953 Blocked
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SPÉCIFICATIONS

Symbole antigène LOX
Nom de l'antigène Lysyl oxidase
Réactivité Human, Mouse
Conjugaison Unconjugated
Clonalité Polyclonal
Type d' Anticorps Primary
Hôte Rabbit
Isotype IgG
Western Blot Yes
ImmunoChemistry Yes
ImmunoFluorescence Yes
Antigen synonyms Protein-lysine 6-oxidase antibody, EC 1.4.3.13 antibody, Lysyl oxidase antibody.
Gene ID 16948, 4015
Mesures de concentration 1.3 mg/ml
Immunogen Synthetic peptide between amino acids 200-300 of the human LOX protein.
Purification Antigen affinity chromatography
Form Liquid
Storage Buffer tris glycine, 0.15M NaCl, 0.05% sodium azide
Température de stockage -20° C, Avoid Freeze/Thaw Cycles
Shipping Temperature Ice
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