- Type d'anticorps:Primaire
- Nom de l'antigène:Cyclin-dependent kinase inhibitor 2A
- Symbole de l'antigène:p19ARF
- Clonalité:Polyclonal
- Conjugaison:FITC (Fluorescein Isothiocyanate)
- Hôte:Rabbit
- ImmunoChimie:Yes
- Isotype:IgG
- Réactivité:Rat,Mouse
- Environmentally Preferable:
- Adsorption croisée:No
- Formulaire:liquid
- Synonymes antigène:CDKN2|p16-INK4|MLM|INK4|P16|p19ARF|p16-INK4a|p16INK4a|p16|CDKN2A|p16INK4|p19|p14|p16INK4A|CDK4I|INK4a|p14ARF|CMM2|ARF|MTS1|TP16
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Température de stockage:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Température de transport:4°C
- Purification:Purified by Protein A
- Cdt:100 µl
P19ARF Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: p19ARF
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Mouse, Rat