- Type d'anticorps:Primaire
- Nom de l'antigène:Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal Domain, 2
- Symbole de l'antigène:CITED2
- Clonalité:Polyclonal
- Conjugaison:Cy3®
- Hôte:Rabbit
- ImmunoChimie:Yes
- Isotype:IgG
- Réactivité:Human,Rat,Mouse
- Environmentally Preferable:
- Adsorption croisée:No
- Formulaire:liquid
- ID de gène:10370
- Synonymes antigène:P35SRJ|MRG1|Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Température de stockage:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Température de transport:4°C
- Immunogène:130-180/193
- Purification:Purified by Protein A
- Cdt:100 µl
Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: CITED2
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype:
Reactivity: