- VPE:10 µG
- Protein/peptide type:Recombinant
- Bron:E. coli
- Species:Human
- Environmentally Preferable:
- Tag sequence:Tag Free
- Storage conditions:Stable for at least 6 months after receipt when stored at −20 °C.
- Biologische activiteiten:Activates human ST2-dependent NF-kappaB pathway. Does not activate mouse ST2-dependent NF-kappaB.
- Protein synonyms:IL-1F11|NF-HEV|Interleukin-33
- Protein/peptide name:IL33
- Zuiverheid:>95% (SDS-PAGE)
- Sequentie:112-270
- Formulering:Lyophilized, Contains PBS.
- Tested applications:Research use
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
Fusion-Tag: Tag Free
This recombinant proteins is for research use only.