N-Arachidonoyl-L-Serine 1% in ethanol , 98%
Leverancier: Cayman Chemical
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Gevaar
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Synoniemen:
ARA-S
Arachidonoyl amides of both amino acids and neurotransmitters such as dopamine have been previously reported in the literature.
(1)N-Arachidonoyl-L-serine (ARA-S) is one such recently isolated endocannabinoid with an unusual activity profile. ARA-S does not bind to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors or vanilloid receptor 1 (VR1). Like cannabidiol, ARA-S (5 mg/kg) antagonizes the hypotensive effects of a 10 mg/kg IV bolus of abnormal cannabidiol (Abn-CBD) in an anesthetized rat blood pressure model.
(2)However, similar to Abn-CBD, ARA-S relaxes isolated rat mesenteric arteries and abdominal aorta as well as increases phosphorylation of Akt and mitogen-activated protein kinase (MAPK) in HUVEC.
(3)The precise mechanisms of action by ARA-S and Abn-DBD in various vascular preparations appears to be different and requires further investigation.
- Purity: ≥98%
- Formulation: A solution in ethanol
- Storage: -20°C
- Stability: ≥ 1 year
Product Description References
1. Bisogno, T.,Melck, D.,Bobrov, M.Y., et al. N-acyl-dopamines: Novel synthetic CB1 cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochemistry Journal 351, 817-824 (2001).
2. Milman, G.,Maor, Y.,Horowitz, M., et al. Arachidonoyl-serine, an endocannabinoid-like bioactive constituent of rat brain. 14th Annual Symposium on the Cannabinoids 133-133 (2004).
3. Milman, G.,Maor, Y.,Abu-Lafi, S., et al. N-arachidonoyl L-serine, an endocannabinoid-like brain constituent with vasodilatory properties. Proceedings of the National Academy of Sciences of the United States of America 103(7), 2428-2433 (2006).
Warning - this product is not for human or veterinary use.
Formule:
C₂₃H₃₇NO₄ MW: 391,5 g/mol Vlampunt: 14 °C (gesloten beker) Opslagtemperatuur: Vriezer |
MDL-nummer:
MFCD08062151 CAS-nummer: 187224-29-9 UN: 1170 ADR: 3,II |
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