Leptomycin B 0,2 mg/ml ≥98% (by HPLC)

Leverancier: Enzo Life Sciences

ALEXALX380100C100EA 186 EUR
ALEXALX380100C100
Leptomycin B 0,2 mg/ml ≥98% (by HPLC)
Leptomycin B

A potent and specific nuclear export inhibitor. In addition to antifungal and antibacterial activities, blocks the cell cycle and is a potent anti-tumor agent.


  • Liquid


Leptomycin B alkylates and inhibits CRM1/exportin 1, a protein required for nuclear export of proteins containing a nuclear export sequence (NES). At low nM concentrations, blocks the nuclear export of many proteins including HIV-1 Rev, MAPK/ERK, and NF-κB/IκB and it stabilizes the expression of p53. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, Iκb, MPF and PKA. Leptomycin B also inhibits the export and translation of many RNAs, including COX-2 and c-Fos mRNAs, by inhibiting export of ribonucleoproteins.

Isolated from Streptomyces sp.


Liquid. In 100% ethanol.


Soluble in methanol or 100% ethanol, Insoluble in water, Unstable in DMSO

Formule: C₃₃H₄₈O₆
Opslagtemperatuur: Vriezer
MDL-nummer: MFCD06795848
CAS-nummer: 87081-35-4

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